Prof. Levanon Erez – Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

Prof. Erez Levanon

Abstract Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs. We designed decoy oligonucleotides, composed of several repeats of…

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