Dr. Omry Koren – Deep microbial analysis of multiple placentas shows no evidence for a placental microbiome

Abstract Objectives To resolve the controversy regarding the presence of a microbiota in the placenta. Design Classical and molecular microbiological study. Setting All samples were collected during caesarean section. Population A total of 28 human placentas and six murine placentas. Methods All 28 human placentas were checked for 16S rRNA gene amplification products. Three locations…

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Dr. Orly Avni – Social-Stress-Responsive Microbiota Induces Stimulation of Self-Reactive Effector T Helper Cells

ABSTRACT Stressful life events are considered a risk factor for autoimmune disorders, though the mechanisms are unclear. Here we demonstrate that chronic social stress induces virulence-associated transcriptional patterns in the murine gut microbiota. The stress-influenced microbiota increased the presence of effector T helper cells in the mesenteric lymph nodes, including myelin-autoreactive cells. Inhibition of the…

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Dr. Omry Koren – Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy

Highlights Bifidobacterium abundance increases in the gut during pregnancy in women and mice Progesterone supplementation alters gut microbial composition in mice and in vitro Progesterone supplementation increases Bifidobacterium abundance in mice and in vitro We suggest that progesterone promotes Bifidobacterium growth during late pregnancy Summary Gestation is accompanied by alterations in the microbial repertoire; however, the mechanisms driving these changes are unknown. Here, we…

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