Dr. Hava Gil-Henn – Invasion and metastasis: the elusive hallmark of cancer

In their seminal review published nearly two decades ago, Hanahan and Weinberg introduced the “hallmarks of cancer” and typified essential biological abilities that are acquired by human cancer [1], including sustained proliferative signaling, resistance to apoptosis, evading growth suppressors, induction of angiogenesis, enabling replicative immortality, and invasion and metastasis. Eleven years later, in 2011, the…

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Dr. Hava Gil-Henn – Hepatitis C Virus Enhances the Invasiveness of Hepatocellular Carcinoma via EGFR-Mediated Invadopodia Formation and Activation

Abstract Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide and the third cause of cancer-related mortality. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, which often results in liver fibrosis, cirrhosis, and eventually HCC. HCV is the most common risk factor for HCC in western countries and leads to a…

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Dr. Meital Gal-Tanamy – Hepatitis C Virus Enhances the Invasiveness of Hepatocellular Carcinoma via EGFR-Mediated Invadopodia Formation and Activation

Abstract Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide and the third cause of cancer-related mortality. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, which often results in liver fibrosis, cirrhosis, and eventually HCC. HCV is the most common risk factor for HCC in western countries and leads to a…

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Dr. Meital Gal-Tanamy – Hepatitis C virus leaves an epigenetic signature post cure of infection by directacting antivirals

Abstract The increasing worldwide prevalence of Hepatocellular carcinoma (HCC), characterized by resistance to conventional chemotherapy, poor prognosis and eventually mortality, place it as a prime target for new modes of prevention and treatment. Hepatitis C Virus (HCV) is the predominant risk factor for HCC in the US and Europe. Multiple epidemiological studies showed that sustained…

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Dr. Hava Gil-Henn – Plasma exosomes stimulate breast cancer metastasis through surface interactions and activation of FAK signaling

Abstract Purpose The interaction between malignant cells and surrounding healthy tissues is a critical factor in the metastatic progression of breast cancer (BC). Extracellular vesicles, especially exosomes, are known to be involved in inter-cellular communication during cancer progression. In the study presented herein, we aimed to evaluate the role of circulating plasma exosomes in the…

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