Dr. Ayal Hendel

Biology and medicine are undergoing a tremendous revolution where the use of advanced technologies, sophisticated bioinformatics and big data, revealing immediate impact on translation to medicine including disease diagnosis, treatment and outcome. Thus the main objective of this proposal that combines clinical and scientific skills is to extend our knowledge on pathways controlling human immunity…

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Nucleic Acids Research, 2019 1–15 doi: 10.1093/nar/gkz477 Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and their implication for RNA and protein interactions K. Shanmugha Rajan1, Tirza Doniger 1, Smadar Cohen-Chalamish1, Dana Chen1, Oz Semo1, Saurav Aryal1, Efrat Glick Saar2, Vaibhav Chikne1, Doron Gerber 1, Ron Unger1, Christian Tschudi3 and Shulamit Michaeli 1,* 1The Mina…

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Abstract Hepatitis C virus (HCV) infection is the leading cause of chronic hepatitis, which often results in liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). HCV possesses an RNA genome and its replication is confined to the cytoplasm. Yet, infection with HCV leads to global changes in gene expression, and chromosomal instability (CIN) in the host…

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The Dangoor Centre For Personalized Medicine

Familial Kaposi’s sarcoma and genetic whole exome analysis Background: Kaposi’s sarcoma (KS) is a rare malignancy most commonly appearing in HIV carriers. In addition to HIV carriers, there are rare families with genetic predisposition for KS, some are Jewish descent from Morocco. Professor Moshe Schaffer identified a few such families in his service as oncologist…

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The first grant of the Dangoor Center for Personalized Medicine has been awarded to a project using innovative epigenetic methods in order to enhance diagnosis and treatment of patients with acute coronary disease. Cardiovascular diseases are defined by the patient’s loss of flexibility in his or her blood vessels or his or her obstructed and…

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