Dr. Ayal Hendel

Genome editing of human cluster of differentiation 34+ (CD34+) hematopoietic stem and progenitor cells (HSPCs) holds great therapeutic potential. This study aimed to optimize on-target, ex vivo genome editing using the CRISPR-Cas9 system in CD34+ HSPCs and to create a clear workflow for precise identification of off-target effects. Modified synthetic guide RNAs (gRNAs), either 2-part gRNA or single-guide RNA (sgRNA),…

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Abstract Background: Cardiovascular disease (CVD) is more frequent in patients with systemic lupus erythematosus (SLE) compared with age- and sex-matched healthy subjects. SLE is an autoimmune disease that is more prevalent in women (9:1). Women tend to develop CVD in post-menopausal years; however, women with SLE may develop endothelial dysfunction and CVD at a younger age…

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Highlights • The enteric nervous and immune systems closely interact to control gut homeostasis. • The gut microbiota impact enteric neuroimmune communications and host immunity. • Microbial dysbiosis disturbs homeostatic enteric innervation and immunocyte activity. • The enteric neuro-immune-microbiota interface impact local and systemic physiology. Over the past decade, our understanding of intestinal immunology has…

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The protein translocated intimin receptor (Tir) from enteropathogenic Escherichia coli shares sequence similarity with the host cellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). The ITIMs of Tir are required for Tir-mediated immune inhibition and evasion of host immune responses. However, the underlying molecular mechanism by which Tir regulates immune inhibition remains unclear. Here we demonstrated that β-arrestin 2,…

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Prof. Erez Levanon

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well as cancer. In addition, the endogenous A-to-I editing…

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Dr. Ayal Hendel

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well as cancer. In addition, the endogenous A-to-I editing…

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Abstract Background Rheumatoid arthritis (RA) is the most common systemic autoimmune disease characterized by chronic systemic inflammation. Half of the deaths of patients with RA are due to cardiovascular diseases (CVD), considered to be 1.5 to −2.0‐fold that in the general population. Patients with RA also experience poor sleep, which by itself is associated with…

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Abstract One approach to understanding perpetration of intimate partner violence (IPV) by men focuses upon their childhood exposure to abuse or neglect as traumatic experiences, which may lead to PTSD symptoms; these symptoms can serve as risk factors for IPV perpetration. Another approach looks at the societal aspects of inequality between men and women as promoting male…

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