Dr. Ayal Hendel

Genome editing of human cluster of differentiation 34+ (CD34+) hematopoietic stem and progenitor cells (HSPCs) holds great therapeutic potential. This study aimed to optimize on-target, ex vivo genome editing using the CRISPR-Cas9 system in CD34+ HSPCs and to create a clear workflow for precise identification of off-target effects. Modified synthetic guide RNAs (gRNAs), either 2-part gRNA or single-guide RNA (sgRNA),…

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Abstract Background: Cardiovascular disease (CVD) is more frequent in patients with systemic lupus erythematosus (SLE) compared with age- and sex-matched healthy subjects. SLE is an autoimmune disease that is more prevalent in women (9:1). Women tend to develop CVD in post-menopausal years; however, women with SLE may develop endothelial dysfunction and CVD at a younger age…

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Highlights • The enteric nervous and immune systems closely interact to control gut homeostasis. • The gut microbiota impact enteric neuroimmune communications and host immunity. • Microbial dysbiosis disturbs homeostatic enteric innervation and immunocyte activity. • The enteric neuro-immune-microbiota interface impact local and systemic physiology. Over the past decade, our understanding of intestinal immunology has…

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