Abstract Chd1 is a chromatin remodeler that is involved in nucleosome positioning and transcription. Deletion of CHD1 is a frequent event in prostate cancer. The Structural Maintenance of Chromosome (SMC) complex cohesin mediates long-range chromatin interactions and is involved in maintaining genome stability. We provide new evidence that Chd1 is a regulator of cohesin. In…

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Abstract The increasing worldwide prevalence of Hepatocellular carcinoma (HCC), characterized by resistance to conventional chemotherapy, poor prognosis and eventually mortality, place it as a prime target for new modes of prevention and treatment. Hepatitis C Virus (HCV) is the predominant risk factor for HCC in the US and Europe. Multiple epidemiological studies showed that sustained…

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Background Controversy surrounds the definition of “normal” and “abnormal” labor. Objective In this study, we used contemporary labor charts to explore labor patterns in large obstetric population (2011–2016). Study Design Detailed information from electronic medical records of live singleton deliveries at term (≥37 weeks of gestation) was extracted. Cases of elective cesarean deliveries, nonvertex presentation,…

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Abstract Objective Pregnancy may affect the disease course of IBD. Both pregnancy and IBD are associated with altered immunology and intestinal microbiology. However, to what extent immunological and microbial profiles are affected by pregnancy in patients with IBD remains unclear. Design Faecal and serum samples were collected from 46 IBD patients (31 Crohn’s disease (CD) and 15…

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Dr. Ayal Hendel

Biology and medicine are undergoing a tremendous revolution where the use of advanced technologies, sophisticated bioinformatics and big data, revealing immediate impact on translation to medicine including disease diagnosis, treatment and outcome. Thus the main objective of this proposal that combines clinical and scientific skills is to extend our knowledge on pathways controlling human immunity…

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Nucleic Acids Research, 2019 1–15 doi: 10.1093/nar/gkz477 Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and their implication for RNA and protein interactions K. Shanmugha Rajan1, Tirza Doniger 1, Smadar Cohen-Chalamish1, Dana Chen1, Oz Semo1, Saurav Aryal1, Efrat Glick Saar2, Vaibhav Chikne1, Doron Gerber 1, Ron Unger1, Christian Tschudi3 and Shulamit Michaeli 1,* 1The Mina…

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